M.D., Professor, Research Educator
I have been a faculty in the Department of Medicine, Rheumatology Division since 1968. My main area of interest is on the relation between the rheumatic autoimmune diseases and carcinogenesis and my research focuses on the identification of signal transduction molecules involved in the pathogenesis of breast cancer and other solid tumors. Currently, I have several ongoing research projects based on data collected with the support of an Ro1 NIH grant. 1. The effect of diet and other factors on the cross talk between the intestinal microbiome and the immune system in breast cancer. 2. Identification of molecular biomarkers of breast cancer risk in a cohort of healthy women undergoing annual screening mammography. Necessary training to participate in these on going research projects include understanding methods used to clone molecular biomarkers from cDNA libraries and to perform homology searches in databases. Students will be directed to perform focused literature searches and will participate in the process of reporting the results and the analysis of the data. Our program offers a rich research experience useful to understand complex pathogenic mechanisms that could be applied to many important parallel fields in internal medicine.
M.D., University of Buenos Aires, School of Medicine, Argentina 1953
Residency in internal medicine Hospital de Clínicas (University Hospital) Buenos Aires, Argentina , 1953-1957
Fellowship In Pediatric Cardiology and Rheumatic Diseases Children Hospital Buenos Aires, Argentina 1957-1960
Physiology, Cellular and Molecular Biology, University of Miami, Graduate School, Coral Gables, Florida 1961-1966
Areas of Research
Research and Professional Experience
1967-1968 Assistant Professor, Medicine and Physiology, University of Miami, SOM,Coral Gables, Florida USA.
1968-1972 Associate Professor of Internal Medicine Wayne State University, School of Medicine, Detroit, Michigan,USA.
1972- Professor of Internal Medicine (Tenure Track), Wayne State University, School of Medicine, Detroit, Michigan, USA.
1996- Karmanos Cancer Institute (Member, Breast Cancer Program
1997- Associate, Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA.
1972-1990 Associate in Biochemistry, Wayne State University, Detroit MI
1968-1999 and 2012-2016 Chief, Division of Rheumatology, WSU School of Medicine, Detroit, MI
1968-1999 and 2013-2016 Rheumatology Fellowship Program Director, Detroit, MI